\u00a9 2022 wikiHow, Inc. All rights reserved. Some also recommend applying the mullein leaf directly to sores and wounds. Approved by our Clinical team | Mar 20, 2020. Klandorf H, et al. If you are unsure on how much you should take mullein, or if it can react with any current medications talk to a physician or healthcare provider. If you have to pee all the time without a reason that you can pinpoint, it might be time for a check-in with your doctor. View abstract. 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