17Beta-estradiol up-regulates vascular endothelial growth factor receptor-2 expression in human myometrial microvascular endothelial cells: role of estrogen receptor-alpha and -beta. ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity. Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling. A fully developed woman generally has a wider pelvis, broader hips, and larger breasts than an adult man. [21], After the first batches of Rubik's Cubes were released in May 1980, initial sales were modest, but Ideal began a television advertising campaign in the middle of the year which it supplemented with newspaper advertisements. The experiment was aimed to test the effect of human VEGFA in EC migration by scratch wound migration assay. by Anne Commire, Waterford, Conn. He received his UK patent (1344259) on 16 January 1974.[16]. Women in World History : a biographical encyclopedia, 17 vls., ed. Social norms that exist in many parts of the world hinder progress towards protecting women from violence. Average Rating: 4.8 [40], Telephone Consumer Protection Act of 1991. You must have JavaScript enabled in your browser to utilize the functionality of this website. Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity. Discover the joy of expanding your musical palette with an acoustic from leading brands like Maton, Fender, Martin and Yamaha. Cheresh The maximum period for a move sequence is 1260:[55] for example, allowing for full rotations, {F x}1260 or {R y}1260 or {U z}1260; not allowing for rotations, {D R' U2 M}1260, or {B E L' F2}1260, or {S' U' B D2}1260; only allowing for clockwise quarter turns, {U R S U L}1260, or {F L E B L}1260, or {R U R D S}1260; only allowing for lateral clockwise quarter turns, {F B L F B R F U}1260, or {U D R U D L U F}1260, or {R L D R L U R F}1260. Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations. Resveratrol attenuates diabetic nephropathy via modulating angiogenesis. We would like to show you a description here but the site wont allow us. LEXIS 46325 (N.D. Cal. "Sinc and S.E. Those who have a checking or savings account, but also use financial alternatives like check cashing services are considered underbanked. In 21 of 27 OECD countries with comparable data, the number of women graduating from university-level programmes is equal to or exceeds that of men. inhibitors against VEGF receptor tyrosine kinases (10). How Meta's Quest Pro could change Hollywood November 04, 2022. Corporate author : UNESCO Corporate author : China National Silk Museum Person as author : Zhao Feng [editor] Person as author : Nosch, Marie Louise [editor] "[129] Duchen states that while "[t]here are women musicians who refuse to play on their looks, the ones who do tend to be more materially successful. The European Union's highest court, the Court of Justice, ruled that the puzzle's shape was not sufficient to grant it trademark protection. There are a number of speedcubing competitions that take place around the world. Mode 2, which is more appropriate for image or video data (where perfect reliability may be a little bit less important), contains no additional error detection or correction bytes, having therefore 2,336 available data bytes per sector. The preceding figure is limited to permutations that can be reached solely by turning the sides of the cube. Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants. [110][111] On 2 December 2017, Grgoire Pfennig announced that he had broken this record, with a 333333 cube, and that his claim had been submitted to Guinness for verification. Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. of VEGF has been shown to improve the efficiency of bone regeneration It is a popular misconception that the term "woman" is etymologically connected to "womb". Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non-Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy. By extension, for cubes of 666 and larger, moves of three layers are notated by the number 3, for example, 3L. However, due to the nature of CAV (linear speed at the inner edge is still only 12, increasing smoothly in-between) the actual throughput increase is less than 30/12; in fact, roughly 20 average for a completely full disc, and even less for a partially filled one. Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling. [28] This is a counterpart to the Source Identification Code (SID), an eight character code beginning with "IFPI" that is usually stamped on discs produced by CD recording plants. The emergence of global university brands and in focus on a more po sitive agen da conn ected with identif ying sets of respon sibilities. The case ruled that an automatic system that may phone a user from a stored number but otherwise not generated in a random or sequential way (such as for two-factor authentication) does not meet this definition under the TCPA. [69], Specific forms of violence that affect women include female genital mutilation, sex trafficking, forced prostitution, forced marriage, rape, sexual harassment, honor killings, acid throwing, and dowry related violence. multiple sclerosis and systemic lupus erythematosus (8). The trademarks have been upheld by a ruling of the General Court of the European Union on 25 November 2014 in a successful defence against a German toy manufacturer seeking to invalidate them. Ecto-5'-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature. Following a bumpy launch week that saw frequent server trouble and bloated player queues, Blizzard has announced that over 25 million Overwatch 2 players have logged on in its first 10 days. The Ninth Circuit Court of Appeals reversed and reinstated the potentially 90 million dollar lawsuit against publishing giant Simon & Schuster. Younger women today are far more likely to have completed a tertiary qualification: in 19 of the 30 OECD countries, more than twice as many women aged 25 to 34 have completed tertiary education than have women aged 55 to 64. Women have significantly less facial and other body hair, have a higher body fat composition, and are on average shorter and less muscular than men. Magic Cube was held together with interlocking plastic pieces that prevented the puzzle being easily pulled apart, unlike the magnets in Nichols's design. According to records obtained by The Wall Street Journal, the government has collected $6,790 of that amount. [48] The puzzle consists of 26 unique miniature cubes, also known as "cubies" or "cubelets". [14] On early cubes, the position of the colours varied from cube to cube. [137][138][139][140] The extent to which femininity is biologically or socially influenced is subject to debate. Many 333 Rubik's Cube enthusiasts use a notation developed by David Singmaster to denote a sequence of moves, referred to as "Singmaster notation". Targeting VEGF in combination with other immune We are proud of our independent corner store since 1967, we love our gear, and we love getting you the right gear for your needs! by Anne Commire, Waterford, Conn. : Yorkin Publ. Discover thousands of sustainable investment opportunities across different asset classes. Its derivation is uncertain, perhaps from an Old English word which has not survived: another theory is that it developed from Old English 'gyrela', meaning 'dress, apparel': or was a diminutive form of a borrowing from another West Germanic Language. Literacy rates are lowest in South and West Asia, and in parts of Sub-Saharan Africa.[120]. In the United States, Rubik was granted U.S. Patent 4,378,116 on 29 March 1983, for the Cube. Many of the occupations that were available to them were lower in pay than those available to men. [17] Although it is widely reported that the Cube was built as a teaching tool to help his students understand 3D objects, his actual purpose was solving the structural problem of moving the parts independently without the entire mechanism falling apart. [19] Because humans inherit mitochondrial DNA only from the mother's ovum, genealogical researchers can trace maternal lineage far back in time. Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A. the female reproductive cycle (3). This page was last edited on 10 December 2022, at 18:10. Many speedcubers continue to practise it and similar puzzles, and compete for the fastest times in various categories. In 2012, women still made up just 6% of the top-ranked Vienna Philharmonic orchestra. 183, 189, and 206 amino acids (aa) in length (4). Software distributors, and in particular distributors of computer games, often make use of various copy protection schemes to prevent software running from any media besides the original CD-ROMs. Though the TCPA is a federal statute, suits brought by consumers against violators are frequently filed in state courts. [19] Ideal wanted at least a recognisable name to trademark; that arrangement put Rubik in the spotlight because the Magic Cube was renamed after its inventor in 1980. The social role of the mother differs between cultures. One of the 333 Cube variants is Rubik's TouchCube. Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein. [2] A track (a group of sectors) inside a CD-ROM only contains sectors in the same mode, but if multiple tracks are present in a CD-ROM, each track can have its sectors in a different mode from the rest of the tracks. On 9 April 1970, Frank Fox applied to patent an "amusement device", a type of sliding puzzle on a spherical surface with "at least two 33 arrays" intended to be used for the game of noughts and crosses. We routinely perform this differentiation protocol and VEGF165 has been reliable in expanding iPSC-derived ECs to sufficient quantities required for us to recellularize rat lung scaffolds which have been decellularized. Even while Rubik's patent application was being processed, Terutoshi Ishigi, a self-taught engineer and ironworks owner near Tokyo, filed for a Japanese patent for a nearly identical mechanism, which was granted in 1976 (Japanese patent publication JP55-008192). Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Mann had a gender-neutral meaning of "human", corresponding to Modern English "person" or "someone"; however, subsequent to the Norman Conquest, man began to be used more in reference to "male human", and by the late 13th century it had begun to eclipse usage of the older term wer. Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. 15-year-old girls tend to show much higher expectations for their careers than boys of the same age. VEGF is required during Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics. The usage meaning 'child of either sex' survived much longer in. Corporate author : UNESCO Corporate author : China National Silk Museum Person as author : Zhao Feng [editor] Person as author : Nosch, Marie Louise [editor] MMP9 processing of HSPB1 regulates tumor progression. [134][135][136] In ancient alchemy, the Venus symbol stood for copper and was associated with femininity.[136]. The World Cube Association maintains a history of world records. September 2013. ISBN 978-0-8400-3204-1. [127] Women are also underrepresented in orchestral conducting, music criticism/music journalism, music producing, and sound engineering. VEGF121 contain basic heparin-binding regions and are [23][29], In September 2020, the Eastern District of Texas found a single missed call using a localized number was enough trigger Article III standing under TCPA. However, the single best time of all tries is also recorded. Angiogenic sprouting is regulated by endothelial cell expression of Slug. Since 2003, the winner of a competition is determined by taking the average time of the middle three of five attempts. Rubik's Cube lends itself to the application of mathematical group theory, which has been helpful for deducing certain algorithms in particular, those which have a commutator structure, namely XYX1Y1 (where X and Y are specific moves or move-sequences and X1 and Y1 are their respective inverses), or a conjugate structure, namely XYX1, often referred to by speedcubers colloquially as a "setup move". [77], The most move optimal online Rubik's Cube solver programs use Herbert Kociemba's Two-Phase Algorithm which can typically determine a solution of 20 moves or fewer. Expansion of human SCID-repopulating cells under hypoxic conditions. (1990) Proc. 227. Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation, Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling, The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b, Ureteral reconstruction with reinforced collagen scaffolds in a porcine model, Mesenchymal Stem Cells Reshape and Provoke Proliferation of Articular Chondrocytes by Paracrine Secretion, The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain, MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. The proangiogenic effect of iroquois homeobox transcription factor Irx3 in human microvascular endothelial cells. Sonys PSVR 2 will be a major test for the VR market November 08, 2022. [citation needed]. By the 16th century, the unsupported word had begun to mean specifically a female: 1546 J. Heywood Dialogue Prouerbes Eng. For example, a CD-ROM drive that can read at 8 speed spins the disc at 1600 to 4000 rpm, giving a linear velocity of 9.6m/s and a transfer rate of 1200 Kbyte/s. The user has to set the colour configuration of the scrambled cube, and the program returns the steps required to solve it.[78]. The size of a disc image created from the data in the sectors will depend on the type of sectors it is using. More generally, sex differentiation of the female fetus is governed by the lack of a present, or functioning, SRY-gene on either one of the respective sex chromosomes. Fender, Ibanez and Music Man all make very regular appearances in the Musos Corner lineup so if you're to lay down some tasty bass lines you've come to the right place. Some algorithms do have a certain desired effect on the cube (for example, swapping two corners) but may also have the side-effect of changing other parts of the cube (such as permuting some edges). [etc. R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells (4). Inhibition of tumor growth and angiogenesis by soluble EphB4. 4052 CAV). The ED50 is 1-6 ng/mL. In 2016, the highest estimated TFR was in Niger (6.62 children born per woman) and the lowest in Singapore (0.82 children/woman). To support the upgrading of midwifery skills the WHO established a midwife training program, Action for Safe Motherhood. Some Cubes have also been produced commercially with markings on all of the squares, such as the Lo Shu magic square or playing card suits. Acoustic guitars are responsible for some of the most well known songs to ever grace human ears. C 06-2893 CW, 2007 U.S. Dist. South Georgia and the South Sandwich Islands, African-American women's suffrage movement, International Federation of Gynecology and Obstetrics, Declaration on the Elimination of Violence against Women, rape during the Bangladesh Liberation War, genocide and rape of Yazidi and Christian women, Organisation for Economic Co-operation and Development, List of elected and appointed female heads of state and government, Nineteenth Amendment to the United States Constitution, commonly performed classical music repertoire, "Definition of girl noun from the Oxford Advanced Learner's Dictionary", "Girls now reaching puberty before 10 a year sooner than 20 years ago", "Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People (version 7)", "Foundational Concepts and Affirming Terminology Related to Sexual Orientation, Gender Identity, and Sex Development", "Genetic Mechanisms of Sex Determination", "Age at menarche in Canada: results from the National Longitudinal Survey of Children & Youth", "What is Assisted Reproductive Technology? Although there have been a huge number of women composers in classical music, from the Medieval period to the present day, women composers are significantly underrepresented in the commonly performed classical music repertoire, music history textbooks and music encyclopedias; for example, in the Concise Oxford History of Music, Clara Schumann is one of the only female composers who is mentioned. [24] By 1981, Rubik's Cube had become a craze, and it is estimated that in the period from 1980 to 1983 around 200million Rubik's Cubes were sold worldwide. To maintain this linear velocity as the optical head moves to different positions, the angular velocity is varied from about 500 rpm at the inner edge to 200 rpm at the outer edge. First, we stacked our store with a massive range of brands to suit every budget, then we filled our store with working Musos who are experts; guys and girls who are passionate about putting the right gear in your hands. The 1 speed rating for CD-ROM (150 Kbyte/s) is different from the 1 speed rating for DVDs (1.32 MB/s). A mass-produced 171717 was later introduced by the Chinese manufacturer YuXin. Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. Cancer Res. If a CD-ROM is read at the same rotational speed as an audio CD, the data transfer rate is 150 Kbyte/s, commonly called "1" (with constant linear velocity, short "CLV"). Macroaxis is a sophisticated yet simple to use personalized wealth optimization service that delivers measurable value in the form of improved return on investment portfolios of self-guided and socially-responsible investors. The underbanked represented 14% of U.S. households, or 18. It is similar to the layer-by-layer method but employs the use of a large number of algorithms, especially for orienting and permuting the last layer. At 52, the linear velocity of the outermost part of the disc is around 65m/s. First, we stacked our store with a massive range of brands to suit every budget, then we filled our store with working Musos who are experts; guys and girls who are passionate about putting the right gear in your hands. This week, information from the Reforma newspaper revealed the way in which that group of hitmen sent by the men of Nemesio Oseguera Cervantes, alias El Mencho , leader of the Jalisco Cartel, Perrong has demanded tens of thousands of dollars in some cases, and most of his suits are settled quickly. There has been an increase in the endorsement of egalitarian gender roles in the home by both women and men. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest. Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. In the event of a willful violation of the TCPA, a subscriber may sue for up to three time the damages, i.e. There are six central pieces that show one coloured face, twelve edge pieces that show two coloured faces, and eight corner pieces that show three coloured faces. signaling pathway include the recombinant antibody against VEGF (Bevacizumab), History of Childbirth. There are 8! CD-i? Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis. This notation uses the same letters for faces except it replaces U with T (top), so that all are consonants. [citation needed]. scammed cellular telephone customers through the use of fraudulent and deceptive advertisements. [12][bettersourceneeded] Different countries have different laws, but age 18 is frequently considered the age of majority (the age at which a person is legally considered an adult). The sum includes forfeiture orders in cases involving robocalling, Do Not Call Registry and telephone solicitation violations. [139][138][140] It is distinct from the definition of the biological female sex,[141][142] as both men and women can exhibit feminine traits. Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. Learn how and when to remove this template message, "Canadian company that owns classic toys Etch A Sketch and Aerobie buys Rubik's Cube for $50M", "The people who are still addicted to the Rubik's Cube", "Jan. 30, 1975: Rubik Applies for Patent on Magic Cube", "25th Anniversa[r]y of Erno Rubik's Magic Cube. embryogenesis to regulate the proliferation, migration, and survival of [130] In popular music, while there are many women singers recording songs, there are very few women behind the audio console acting as music producers, the individuals who direct and manage the recording process. [47], A standard Rubik's Cube measures .mw-parser-output .frac{white-space:nowrap}.mw-parser-output .frac .num,.mw-parser-output .frac .den{font-size:80%;line-height:0;vertical-align:super}.mw-parser-output .frac .den{vertical-align:sub}.mw-parser-output .sr-only{border:0;clip:rect(0,0,0,0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}5.6 centimetres (2+14in) on each side. A settlement was finally approved by Judge Claudia Wilken on August 6, 2010, which would pay out $175 to each class member who files a claim. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. Some women are denied reproductive rights. MODE1 vs MODE2? Approximately 86% of maternal deaths occur in sub-Saharan Africa and South Asia, with sub-Saharan Africa accounting for around 66% and Southern Asia accounting for around 20%. immune checkpoint signals to evade detection by immune cells. Each of the six centre pieces pivots on a screw (fastener) held by the centre piece, a "3D cross". 1 month, 2 to 8 C under sterile conditions after reconstitution. 227(B); FCC Regulations exempt non-solicitation calls. Discover thousands of sustainable investment opportunities across different asset classes. [52] To put this into perspective, if one had one standard-sized Rubik's Cube for each permutation, one could cover the Earth's surface 275 times, or stack them in a tower 261 light-years high. [58][59], Reproductive rights are legal rights and freedoms relating to reproduction and reproductive health. Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis. Group solving (30 minutes): On 21 November 2012, at the, This page was last edited on 6 December 2022, at 10:04. Vertical front to back planes were noted as books, with book 1 or B1 starting from the left. The defendants, the publishing company that contracted for the transmission of the promotional messages and the service provider that actually sent the messages, argued that the named subscriber, the child's mother, had consented to the transmission of promotional messages when, to receive a free ringtone, she checked the box in an online form labeled "Yes! [62] Traditionally, middle class women were involved in domestic tasks emphasizing child care. In Colombia, the armed conflict has also resulted in increased sexual violence against women. We would like to show you a description here but the site wont allow us. [25][26], In July 2020, the US Supreme Court found the "government-debt" exception to the TCPA was unconstitutional. Such algorithms are often simpler than the ones without side effects and are employed early on in the solution when most of the puzzle has not yet been solved and the side effects are not important. After being challenged in court by the telemarketing industry,[citation needed] the National Do Not Call Registry received Congressional ratification in the speedy enactment of Do-Not-Call Implementation Act. In 2011, Guinness World Records awarded the "largest order Rubiks magic cube" to a 171717 cube, made by Oskar van Deventer. fetus and adult (1-3). In 2013, the Philadelphia Federal Appeals Court held that consent to receive calls from collectors, banks, or telemarketers to consumers' cell phones may be revoked by the consumer.[10]. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. "Distaff" is an archaic adjective derived from women's conventional role as a spinner, now used only as a deliberate archaism. In many parts of the world, women with dependent children are expected to stay at home and dedicate all their energy to child raising, while in other places mothers most often return to paid work (see working mother and stay-at-home mother). However, the centre cube of each of the six faces is merely a single square faade; all six are affixed to the core mechanism. Ian McShane, Matthew McFadyen, Rufus Sewell and David Oakes steal the Gig. and R. Kurzrock They are produced in both men and women, but their levels are significantly higher in women, especially in those of reproductive age. You must have JavaScript enabled in your browser to utilize the functionality of this website. 227. [114][115], Google has released the Chrome Cube Lab in association with[116] Ern Rubik. [67], Violence against women remains a widespread problem, fueled, especially outside the West, by patriarchal social values, lack of adequate laws, and lack of enforcement of existing laws. Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association. Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin. 2d 881 (2012). [104] Chinese manufacturer ShengShou has been producing cubes in all sizes from 222 to 151515 (as of May 2020), and have also come out with a 171717.[105]. Invest in what you are passionate for or care about. [1], Taking advantage of an initial shortage of cubes, many imitations and variations appeared, many of which may have violated one or more patents. 2 Early enzymology-demystifying life. The bodies of three men were found hanging from a bridge in a suspected drug cartel crime. isoform, followed by VEGF121 and A solution commonly used by speedcubers was developed by Jessica Fridrich. If bass guitars get the hairs standing up on the back of your neck, stop what you're doing right now. In January 2019, the global average of women in national assemblies was 24.3%. Using the front face as a reference view, table moves were left or right, book moves were up or down, and window moves were clockwise or anticlockwise. They can also coexist with audio CD tracks, which is the case of mixed mode CDs. We would like to show you a description here but the site wont allow us. (When arrangements of centres are also permitted, as described below, the rule is that the combined arrangement of corners, edges, and centres must be an even permutation.) Prohibits autodialed calls that engage two or more lines of a multi-line business. However, with marker pens, one could, for example, mark the central squares of an unscrambled Cube with four coloured marks on each edge, each corresponding to the colour of the adjacent face; a cube marked in this way is referred to as a "supercube". The CD-ROM was announced in 1984[7] and introduced by Denon and Sony at the first Japanese COMDEX computer show in 1985. Illustrated edition deluxe limited to 1,000 numbered copies Of those, about 25 million were considered as unsafe. Multiple bands in gel are due to glycosylation. We would like to show you a description here but the site wont allow us. D, 'The boy thy husbande, and thou the gyrle his wyfe.' Here at Musos Corner, the things that matter to Musos, matter to us. DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells. Natl. The Rubik's Cube is a 3-D combination puzzle originally invented in 1974 by Hungarian sculptor and professor of architecture Ern Rubik.Originally called the Magic Cube, the puzzle was licensed by Rubik to be sold by Pentangle Puzzles in the UK in 1978, and then by Ideal Toy Corp in 1980 via businessman Tibor Laczi and Seven Towns founder Tom Kremer. The Rubik's Cube is a 3-D combination puzzle originally invented in 1974 by Hungarian sculptor and professor of architecture Ern Rubik.Originally called the Magic Cube, the puzzle was licensed by Rubik to be sold by Pentangle Puzzles in the UK in 1978, and then by Ideal Toy Corp in 1980 via businessman Tibor Laczi and Seven Towns founder Tom Kremer. 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expression mediates hypoxia-induced pathological retinal neovascularization, Group V secreted phospholipase A2 plays a protective role against aortic dissection, Hydrogel Network Dynamics Regulate Vascular Morphogenesis, Amyloid-&beta Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells, iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome, Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability, Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer, Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2, Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity, Suprachoroidal gene transfer with nonviral nanoparticles, PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression invitro and invivo, Role and therapeutic effects of skeletal muscle-derived non-myogenic cells in a rat myocardial infarction model, Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution, Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways, Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling, Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis, Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer, Blue-violet light decreases VEGFa production in an in vitro model of AMD, Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion, Cardiomyocyte d-dopachrome tautomerase protects against heart failure, Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation, Vascular endothelial growth factor 165 inhibits pro-fibrotic differentiation of stromal cells via the DLL4/Notch4/smad7 pathway, Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair, MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase, A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis, Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy, Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation, CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients, Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin, Hydroxytyrosol and Other Bioactive Compounds, Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway, Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation, Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear, Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A, Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies, Effect of recombinant human vascular endothelial growth factor on testis tissue xenotransplants from prepubertal boys: a three-case study, Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by modulating antiangiogenic and proapoptotic pathways in vitro and in vivo, Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates, Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells, Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations, Non-proteolytic calpain-6 interacts with VEGFA and promotes angiogenesis by increasing VEGF secretion, Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability, Nuclear localization of the tyrosine kinase BMX mediates VEGFR2 expression, 6'-Sialylgalactose inhibits vascular endothelial growth factor receptor 2-mediated angiogenesis, Heparin potentiates Avastin-mediated inhibition of VEGF binding to fibronectin and rescues Avastin activity at acidic pH, Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function, Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation, Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells, VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells, Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis, In-vitro binding analysis of anti-human vascular endothelial growth factor antibodies bevacizumab and aflibercept with canine, feline, and equine vascular endothelial growth factor, Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility, Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells, Dual-functional gelatin-capped silver nanoparticles for antibacterial and antiangiogenic treatment of bacterial keratitis, Therapeutic effect of Cnidium officinale Makino extract on ovariectomized hind-limb ischemic mice, Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau, Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett's associated esophageal adenocarcinoma, Exosomes Derived from Human Induced Pluripotent Stem Cells-Endothelia Cells Promotes Postnatal Angiogenesis in Mice Bearing Ischemic Limbs, A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells, Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering, CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation, Rapid Production of Human VEGF-A following Intradermal Injection of Modified VEGF-A mRNA Demonstrated by Cutaneous Microdialysis in the Rabbit and Pig In Vivo, G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2 and TAB1-TAB3 dependent pathway in endothelial cells, Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology, Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application, Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation, The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply affects the RTKs-AKT-GSK3?-eNOS signaling pathway and endothelial cells survival, Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming, The addition of a polyglutamate domain to the angiogenic QK peptide improves peptide coupling to bone graft materials leading to enhanced endothelial cell activation, Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels, Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model, CCL27/CCL28-CCR10 CHEMOKINE SIGNALING MEDIATES MIGRATION OF LYMPHATIC ENDOTHELIAL CELLS, Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain, Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression, Bevacizumab or fibronectin gene editing inhibits the osteoclastogenic effects of fibroblasts derived from human radicular cysts, VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes, A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis, Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability, VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a ?1 integrin/VEGFR autocrine loop, Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis, Preparation of iPS cell-derived CD31+ endothelial cells using three-dimensional suspension culture, Telatinib is an effective targeted therapy for pseudomyogenic hemangioendothelioma, WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development, Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing, Preclinical Evaluation of ADVM-022, a Novel Gene Therapy Approach to Treating Wet Age-Related Macular Degeneration, VEGF may contribute to macrophage recruitment and M2 polarization in the decidua, Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner, Endoglin interacts with VEGFR2 to promote angiogenesis, EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF, Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer, Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response, RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes, The transcription factor Vezf1 represses the expression of the antiangiogenic factor d2 in endothelial cells, ?-Escin Effectively Modulates HUVECS Proliferation and Tube Formation, Investigating Colorimetric Protein Array Assay Schemes for Detection of Recurrence of Bladder Cancer, Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response, Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs, Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis, IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma, Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab, Sensory neuronal sensitisation occurs through HMGB-1/ RAGE and TRPV1 in high glucose conditions, Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies, Effects of concentrated growth factor on proliferation, migration, and differentiation of human dental pulp stem cells in vitro, Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy, The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development, A safety and immunogenicity study of immunization with hVEGF26-104/RFASE in cynomolgus monkeys, MicroRNA-134 inhibits osteosarcoma angiogenesis and proliferation by targeting the VEGFA/VEGFR1 pathway, Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3, Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis, Establishment of a three-dimensional model to study human uterine angiogenesis, Antiangiogenic effect of dasatinib in murine models of oxygen-induced retinopathy and laser-induced choroidal neovascularization, Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells, Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats, Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis, Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy, MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis, Vertical bone regeneration using rhBMP-2 and VEGF, Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism, A randomized, single-blind, Phase I trial (INVICTAN-1) assessing the bioequivalence and safety of BI 695502, a bevacizumab biosimilar candidate, in healthy subjects, Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells, Inhibition of VEGF-Induced VEGFR-2 Activation and HUVEC Migration by Melatonin and Other Bioactive Indolic Compounds, Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis, TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels, Gelatin device for the delivery of growth factors involved in endochondral ossification, Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina, Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis, The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis, TSLP promotes angiogenesis of human umbilical vein endothelial cells by strengthening the crosstalk between cervical cancer cells and eosinophils, TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation, Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations, Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis, Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis, PM2.5 exposure decreases viability, migration and angiogenesis in human umbilical vein endothelial cells and human microvascular endothelial cells, MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2, Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors, Inhibition of Single Routes of Intracellular Signaling is Not Sufficient to Neutralize the Biphasic Disturbance of a Retinal Endothelial Cell Barrier Induced by VEGF-A165, Vascular Endothelial Growth Factor in Cartilage Development and Osteoarthritis, Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics, Apatinib, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Suppresses Pathologic Ocular Neovascularization in Mice, Ehmt2/G9a controls placental vascular maturation by activating the Notch pathway, Efficacy of aflibercept (EYLEA()) on inhibition of human VEGF in vitro, Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using (111)In-bevacizumab, In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor, Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach. 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